WebMay 31, 2016 · DISC1 is an 854 amino acid coiled-coiled scaffold protein that interacts with other proteins such as PDE4B, NDE1/NDEL1 and GSK3β, which have themselves been linked to psychiatric disorders [ 10 – 12 ]. A number of studies have used mutant mice to test the cellular functions of Disc1. WebHere, we study a mouse strain with a truncating lesion in the endogenous Disc1 ortholog designed to model the effects. Carefully designed animal models of genetic risk factors are likely to aid our understanding of the pathogenesis of schizophrenia. Here, we study a mouse strain with a truncating lesion in the endogenous Disc1 ortholog designed ...

DISC1 regulates astrogenesis in the embryonic brain via

WebJun 11, 2015 · Overexpression of DISC1 via an adeno-associated virus in the hippocampus reduces the levels of soluble A β 40 and A β 42, the density of A β plaques and, importantly, rescues cognitive deficits... WebDifferent mutant DISC1 models induced variable social behavior in mice (53) (54)(55). DISC1 overexpression did not influence social preference in rats. However, social memory was disrupted in ... malarone and diabetes

DISC1 (Disrupted-in-Schizophrenia-1) Regulates …

WebDISC1 is a scaffolding protein found abundantly at the spines ( Kirkpatrick et al., 2006 ), where it interacts with several proteins involved in intracellular signaling, neurite … WebSep 3, 2013 · DISC1 was discovered in a Scottish pedigree in which a chromosomal translocation that breaks this gene segregates with psychiatric disorders, mainly … WebFeb 9, 2024 · HER2 overexpression occurs in 10–20% of breast cancer patients. HER2+ tumors are characterized by an increase in Ki67, early relapse, and increased … malarone bnf children