WebMay 10, 2024 · Due to the short half-life of EIPA in vivo (31.2±2.5 min) 68, at 2 h after the first EIPA injection, the mice were repeatedly injected i.p. with 30 μg g −1 body weight of EIPA or vehicle. WebMacropinocytic dextran facilitates KRAS-targeted delivery while reducing drug-induced tumor immunity depletion in pancreatic cancer . ... EIPA is a highly specific inhibitor of macropinocytosis, and the entry of macropinocytic substrates is disturbed by EIPA administration . A total of 100,000 cells were first seeded in 12-well plates and ...
5-(N-Ethyl-N-isopropyl)amiloride 1154-25-2 - Sigma-Aldrich
WebEIPA is a TRPP3 channel inhibitor with an IC50 value of 10.5 μM, EIPA also inhibits Sodium-hydrogen exchangers (NHE) and macropinocytosis [1]. In Chinese hamster ovary cells, EIPA is a Na + /Ca 2+ exchange (NCX) inhibitor that inhibits ET-1-induced continuous increase of intracellular Ca 2+ concentration. WebAug 21, 1999 · 5-(N-Ethyl-N-isopropyl)-amiloride, an Na(+)-H(+) exchange inhibitor, protects gerbil hippocampal neurons from ischemic injury The effect of the selective Na(+)/H(+) antiporter inhibitor 5-(N-ethyl-N-isopropyl)-amiloride (EIPA) on cerebral ischemia/reperfusion injury was evaluated in the Mongolian gerbil. lakeside glass highland park il
Macropinocytosis dependent entry of Chikungunya virus into …
WebMay 27, 2024 · Treatment with endocytosis inhibitors EIPA, chlorpromazine, MBCD, and cytochalasin-D showed potential to inhibit antibody internalization; however, only MBCD resulted in significantly increased sensitivity to neutrophil-mediated ADCC in … WebEIPA also inhibits Na+/H+-exchanger (NHE) and macropinocytosis. In Vitro:In the presence of 500 μM amiloride, 100 μM EIPA, 10 μM benzamil, and 10 μM phenamil, 45Ca2+ uptake decreases from 79±9 to 46±4 (58% remaining), 27±4 (34%), 29±5 (37%), and 38±4 (48%) pmol/oocyte/30 min (n=6, P=0.008), respectively. WebAnticancer therapies targeting macropinocytosis. Drug conjugates containing compounds that activate macropinocytosis in addition to anticancer drugs promote cancer treatment. … lakeside golf carts morgantown