WebMay 11, 2024 · To investigate the role of the cGAS-IRF3 pathway in mice, we fed mice the Lieber-DeCarli diet, a classic model for studying alcohol-induced liver injury . We found that protein levels of cGAS, TBK1, IRF3, and phosphorylated IRF3 (pIRF3) were elevated markedly in liver tissue of alcohol-fed mice (Fig. 1D). WebSep 1, 2006 · IRF3 is constitutively expressed. It resides in the cytosol in latent form and undergoes nuclear translocation following viral infection. Before this translocation, specific serine residues in...
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WebApr 5, 2024 · This stimulates organization of cytosolic cGAS onto the mtDNA-CAP, and subsequent activation of the cGAS-STING-IRF3 pathway. TGF-β is unable to induce conversion of HSC from a quiescent to a trans-differentiated phenotype in the absence of mtDNA, VDAC or STING. Trans-differentiation by TGF-β is blocked by a STING inhibitor … WebOur results suggest that the STING-IRF3 pathway promotes hepatocyte injury and dysfunction by inducing inflammation and apoptosis and by disturbing glucose and lipid metabolism. This pathway may be a novel therapeutic target for preventing NAFLD development and progression. crystal palace v everton live stream
STING-IRF3 pathway links endoplasmic reticulum stress with ... - PNAS
IRF3 is a member of the interferon regulatory transcription factor (IRF) family. IRF3 was originally discovered as a homolog of IRF1 and IRF2. IRF3 has been further characterized and shown to contain several functional domains including a nuclear export signal, a DNA-binding domain, a C-terminal IRF association … See more Interferon regulatory factor 3, also known as IRF3, is an interferon regulatory factor. See more IRF3 has been shown to interact with IRF7. See more • Pitha PM, Au WC, Lowther W, Juang YT, Schafer SL, Burysek L, Hiscott J, Moore PA (1999). "Role of the interferon regulatory factors (IRFs) in virus-mediated signaling and regulation of cell growth" See more • Interferon+Regulatory+Factor-3 at the U.S. National Library of Medicine Medical Subject Headings (MeSH) • FactorBook IRF3 See more WebIRF3 and IRF7 were altered in 5% and 6% of all TCGA STAD patients. Further analysis revealed that IRF7 was significantly associated with the abundance of immune cells (B … WebThe induction of type I interferons through the transcription factor interferon regulatory factor 3 (IRF3) is considered a major outcome of stimulator of interferon genes (STING) activation that drives immune responses against DNA viruses and tumors. crystal palace versus southampton