WebPhenotypic analysis of peripheral T-lymphocytes following SHIV-challenge. (a) The percentage of CD4+, CD4+CD8+, and CD8+ T-cells expressing CCR5+ was determined by flow cytometry throughout the ... Web15 Feb 2024 · Challenge Phase and SHIV in Blood and Tissues. Macaques were challenged intrarectally (IR) each week with 5000 TCID 50 units (by TZM-bl assay) of heterologous Tier 2 clade C SHIV-1157ipd3N4 virus until all control NHPs were infected. Four IR exposures to SHIV-1157ipd3N4 infected all controls and all SAd7+Protein vaccinated NHPs.

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Web24 Jul 2024 · We have reported that AAV1-delivered rh-eCD4-Ig I39N protected four of four rhesus macaques from four infectious challenges with SHIV-AD8, with a final challenge at 34 weeks after AAV1 inoculation . We continued this study through week 60, when rh-eCD4-Ig I39N concentrations for the four macaques were 23, 30, 34, and 52 μg/ml (fig. S1A). Web28 Aug 2024 · For discovery analysis, cryopreserved PBMCs from 21 rhesus monkeys were selected from the vaccine arms of two studies where partial efficacy was observed, namely, the Ad26/gp140 arm of the 09-11 SIV challenge study (n = 10) and the Ad26/gp140 arm of the 13-19 SHIV challenge study (n = 11) . We measured whole-transcriptome gene … bastian janotta

Advancing an HIV vaccine; advancing vaccinology - Nature

Web24 Oct 2013 · Immunization of rhesus macaques against Gag of SIV resulted in a more rapid appearance of Env antibodies after infection with SIV or SHIV challenge viruses although the vaccines lacked an Env component. We therefore explored whether T helper cells specific for internal HIV proteins could provide intrastructural help for Env-specific B cells and thus … Web1 Mar 2008 · After rectal challenge with SHIV 89.6P, all vaccinated and naive animals became infected. However, most of the vaccinated animals showed significant control of viremia and protection from CD4(+) T cell loss and AIDS progression compared to the control animals. WebSHIV challenge studies have determined the neutralizing antibody titers that correlate with protection for passive and active immunization and enabled complementary human and nonhuman primate studies of vaccine development. SHIV models of latency continue to evolve, aided by descriptions of SHIV persistence on ART and the proviral landscape. liemi kamppi lounas