WebCTLA-4-Fc induced tryptophan catabolism can inhibit mitogen-induced CD4 + T cells activation without influencing CD8 + cells, but did not control CD25 nor Foxp3 expression in BM cells. Significantly higher expression of selected IDO-pathway genes was detected on peripheral monocytes isolated from RA as compared to healthy controls.Webthe serum. Tryptophan degradation by IDO was more promi-nent in patients with high grade or active disease, as previously reported.16 Tryptophan degradation was also associated with rel-ative lymphopenia, a phenomenon that has also been observed in patients with myelodysplastic syndromes.17 Low tryptophan lev-

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